When you're taking exemestane, a type of aromatase inhibitor used to treat hormone-receptor-positive breast cancer in postmenopausal women. Also known as Aromasin, it works by blocking estrogen production, which helps slow cancer growth. But for many, this benefit comes with an unexpected side effect: hair thinning, a gradual reduction in hair density that can feel sudden and distressing.
Exemestane doesn’t cause hair loss the way chemotherapy does. Instead, it quietly lowers estrogen levels—hormones that help keep hair follicles in the growth phase. When estrogen drops, hair may enter the resting phase sooner, leading to more shedding and less regrowth. This isn’t rare: studies show up to 20% of women on aromatase inhibitors report noticeable thinning, especially after 6–12 months. It’s not the same as male-pattern baldness. It’s more like your hair feels finer, your ponytail smaller, or your scalp more visible when you part it. And unlike temporary chemo hair loss, this change can linger as long as you’re on the drug.
Not everyone experiences it, and severity varies. Women with a family history of thinning hair, those already in perimenopause, or those with low baseline estrogen levels tend to notice it more. It’s also more common in people who’ve had prior hormonal shifts—like after pregnancy or stopping birth control. What’s often missed is that hormonal hair loss, a reversible condition tied to estrogen changes isn’t always permanent. Some women see improvement after switching to another aromatase inhibitor, like anastrozole, or adding low-dose topical minoxidil. Others find relief through simple changes: switching to gentler shampoos, avoiding tight hairstyles, or managing stress, which can worsen shedding.
There’s no one-size-fits-all fix, but you’re not alone in this. Many women on exemestane face the same quiet struggle—balancing cancer treatment with self-image. The good news? You can talk to your oncologist about it. They can check your hormone levels, rule out other causes like thyroid issues or iron deficiency, and suggest options that don’t interfere with your treatment. Some clinics even offer hair loss support programs with dermatologists who specialize in hormonal changes.
Below, you’ll find real patient stories and clinical insights about how exemestane affects hair, what helps, what doesn’t, and how to tell if what you’re seeing is normal or something that needs attention. This isn’t about quick fixes—it’s about understanding your body while staying on track with your health.
Exemestane can cause gradual hair thinning in up to 30% of users. Learn the science behind it, what actually helps, and how to cope emotionally without compromising your treatment.
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