Bupropion Price: What You Pay and Where to Find the Best Deals

When you’re taking bupropion, a prescription medication used to treat depression and help people quit smoking. Also known as Wellbutrin, it’s one of the most common antidepressants that doesn’t cause weight gain or sexual side effects—making it a top pick for many. But if you’ve checked your pharmacy receipt lately, you’ve probably noticed the price can jump from $10 to over $100 for a month’s supply. Why the big difference? It’s not magic. It’s brand vs. generic, insurance rules, and where you buy it.

Most people take generic bupropion, the same active ingredient as Wellbutrin but without the brand name markup. Also known as bupropion hydrochloride, this version is what most clinics prescribe now. You’ll find it sold as bupropion XL, the extended-release form that’s taken once daily. Also known as Wellbutrin XL, this version is especially popular for depression and quitting smoking because it lasts longer and causes fewer stomach issues. The cost? At major pharmacies like Walmart or Costco, you can get 30 tablets of 150mg generic bupropion for as low as $8 with a coupon. Without insurance, brand-name Wellbutrin XL can cost $300+—but you rarely need it.

What else affects the price? Your location, pharmacy chain, and whether you use a mail-order service. Some online pharmacies offer discounts if you buy 90 days at a time. And don’t forget: bupropion is often used for smoking cessation, a FDA-approved use that’s covered by many insurance plans. Also known as Zyban, the same pill you take for depression is used here—just at a different dosing schedule. If you’re using it to quit smoking, your plan might cover it even if it doesn’t cover antidepressants. Always ask your pharmacist to check both uses.

There’s also a difference between bupropion SR (twice daily) and XL (once daily). SR is usually cheaper, but XL is easier to stick with. If you’re switching from one to the other, your doctor might adjust the dose. Don’t assume they’re the same—dosage isn’t always 1:1.

And yes, prices vary by country. In Australia, Canada, or the UK, generic bupropion is often under $20. Americans pay more because drug pricing works differently here. That’s why many people turn to verified international pharmacies—legally and safely—when they’re paying out of pocket.

Below, you’ll find real comparisons between bupropion and other antidepressants, how it stacks up against nicotine patches, and where people are actually buying it for the lowest cost. No fluff. Just what you need to know before you pay next time.